Navigating the collaborative pathways in HIV vaccine discovery...in this edition of the ACO E-Bulletin / Images not displaying below? Enjoy this online
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Canadian HIV Vaccine Initiative (CHVI)
Research and Development
Alliance Coordinating Office (ACO)
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Navigating the collaborative pathways in HIV vaccine discovery
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New research by a team of Yale and Johns Hopkins investigators is building on the momentum gained in HIV vaccine discovery. The study published January 7 in Nature shows that a broad immune response is needed to clear latent HIV, and the scientists have identified a potential method to "train the immune system to detect, attack and destroy mutant HIV once coaxed out of its latent state". The implications for this trial are far reaching and could provide future directions for the development of a therapeutic vaccine. Meanwhile a team of Montreal researchers recently identified "a particular conformation of HIV envelope that is specifically targeted by antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies", which suggests the virus tightly controls the exposure of certain envelope epitopes at the surface of infected cells. You can read more online.
Here in Canada we are continuing to build on international collaborations needed for successful outcomes in HIV vaccine research and development. Many collaborative meetings are on the horizon. Our Scientific Advisor Dr. Allan Ronald is co-chairing a session at the University of Nairobi/University of Manitoba HIV/AIDS Collaborative Centre Annual Meeting in Nairobi, Kenya, January 26 to 30, and he will deliver a presentation at the Afri-Can Forum-2 in Johannesburg, South Africa Feb. 16 to 18, 2015. This meeting aims to promote inter-team communications and collaboration among the seven GHRI-funded Canadian-African capacity building networks and the five CHVI/CIHR large team grant recipients.
We are also gearing up for our 2015 ACO Annual CHVI R&D Alliance Meeting, to be held in Toronto on April 30, 2015 as an ancillary session to the 24th Annual Canadian Conference on HIV/AIDS Research — CAHR 2015. Our Annual Meeting will provide a forum for HIV vaccine research and development stakeholders to share best practices, outcomes and future needs in regards to national and international partnerships and collaborations. We hope you can join us. Details will be released in forthcoming editions of the ACO E-bulletin, or visit our website at http://alliance-aco.ca for more information.
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News and Features
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HIV R4P 2014 Video Feature
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As part of the recap on HIV Research for Prevention (HIV R4P) Conference in Cape Town, South Africa we are profiling some Canadian researchers and their poster presentations. This month we feature the work of Melissa Smith, a University of Manitoba PhD candidate.
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Vancouver team adds chapter to AIDS Encyclopedia
Two graduate students from Simon Fraser University have contributed a chapter to Encyclopedia of AIDS — the largest comprehensive reference work for HIV/AIDS researchers around the world.
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Funding Opportunities
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Canadian Institutes of Health Research
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Other : Planning and Dissemination Grants – Institute Community Support (Winter 2015 Competition)
Application Deadline: February 17, 2015
$100,000 is available to fund applications relevant to the CIHR HIV/AIDS Research Initiative
LEARN MORE
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Operating Grant: Transitional Operating Grant: 2014-2015 Priority Announcements
Application Deadline: March 2, 2015
HIV/AIDS (HOP/HHP/HBF)
LEARN MORE
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Catalyst Grant : HIV/AIDS Community-Based Research (2015)
Application Deadline: April 15, 2015
The total amount available for this funding opportunity is $198,000, enough to fund approximately six grants. The maximum amount per grant is $33,000 for up to one year.
LEARN MORE
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Michael Smith Foundation for Health Research (MSFHR) Post-Doctoral Fellowships
Letter of intent deadline: March 17, 2015
Full application deadline: April 20, 2015
LEARN MORE
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Scholarship Opportunities
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RAMP Scholars:
The Research and Mentorship Program (RAMP) aims to recruit and retain a new generation of HIV vaccine researchers by providing structured mentorship and project funding to minority medical students. LEARN MORE.
→ Projects: 8-16 week or 9-12 month mentored research projects
→ Eligibility: Black and Latino/ U.S. medical students
→ Deadline: All materials due January 28, 2015
SHAPe Scholars:
The South African HVTN AIDS Vaccine Early Stage Investigator Programme (SHAPe) aims to expand and strengthen the contribution of South African investigators to HIV vaccine research through a structured research, mentorship and PhD program. LEARN MORE.
→ Projects: Structured mentoring and 36 months of funding including salary, research-related costs, and participation in career development activities. Support may be available to cover PhD program fees.
→ Eligibility: South African MD early stage investigators
Non-Human Primate Early Stage Investigator Scholars:
The Non-Human Primate (NHP) Early Stage Investigator Scholar Program aims to attract and retain promising young investigators interested in improving NHP models that support preventive HIV vaccine development, and provide a framework for ongoing ESI mentorship that will foster increased collaboration between clinical and NHP scientists addressing common questions in vaccine discovery.
→ Contact: judren@fredhutch.org
→ Projects: 1-2 year mentored research projects.
→ Eligibility: Investigators within 10 years of completing an MD or PhD degree currently conducting non-human primate research.
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Career Opportunities
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International AIDS Society
Senior Manager, Communications
deadline January 30, 2015.
International AIDS Vaccine Initiative
Director, Laboratory Program, Africa
Nairobi, Kenya
Director, Socio Behavioral Researcher
Johannesburg, South Africa
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Global HIV Vaccine Enterprise
The Global HIV Vaccine Enterprise Secretariat has an immediate opening for a Managing Director of External Affairs to lead their communications and external relations efforts.
READ MORE
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New Research
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The HIV-1 gp120 CD4-Bound Conformation Is Preferentially Targeted by Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies in Sera from HIV-1-Infected Individuals
J Virol 2015 Jan 1;89(1):545-51. doi: 10.1128/JVI.02868-14.
Epub 2014 Oct 22.
Veillette M, Coutu M, Richard J, et. al
Canadian researchers have identified a particular conformation of HIV-1 envelope that is specifically targeted by antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies present in sera from HIV-1-infected individuals. This observation suggests that HIV-1 developed sophisticated mechanisms to minimize the exposure of these epitopes at the surface of infected cells.
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An HIV-1 Envelope Immunogen with W427S Mutation in CD4 Binding Site Induced More T Follicular Helper Memory Cells and Reduced Non-Specific Antibody Responses
PLOS One, December 29, 2014; DOI: 10.1371/journal.pone.0115047
Hao-Tong Yu H-T, Tian D, Wang J-Y, et. al.
The CD4 binding site (CD4BS) of the HIV-1 envelope glycoprotein (Env) contains epitopes for broadly neutralizing antibody (nAb) and is the target for the vaccine development. However, the CD4BS core including residues 425-430 overlaps the B cell superantigen site and may be related to B cell exhaustion in HIV-1 infection.
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Annual Update
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Annual Update PDF
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You are receiving this email because you registered to receive news updates from the Canadian HIV Vaccine Initiative (CHVI) Research and
Development Alliance Coordinating Office
or you are a member of a CHVI-funded
project team.
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Follow Us:
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Address
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ALLIANCE COORDINATING OFFICE
International Centre for Infectious Diseases
515 Portage Avenue
Winnipeg, MB, Canada
R3B 2E9
Tel.: 204 946 0908
Fax: 204 946 0927
email:
aco@icid.com
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About Us
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The CHVI Research and Development Alliance Coordinating Office (ACO) was established by the Government of Canada and the Bill & Melinda Gates Foundation in November 2011 at the International Centre for Infectious Diseases (ICID), a
not-for-profit,
non-governmental organization based in Winnipeg.
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White Paper
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The ACO has developed a White Paper to foster effective coordination of key players across the Canadian HIV vaccine research landscape.
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Read more
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Conferences
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February 16 to 18, 2015
Afri-Can Forum-2
Johannesburg, South Africa
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February 23 to 26, 2015
Conference on Retroviruses and Opportunistic Infections (CROI 2015)
Seattle, United States
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March 22 to 27, 2015
Keystone Symposium: HIV Vaccines (X5)
Banff, Canada
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April 30 to May 3, 2015
CAHR 2015
Toronto, Canada
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May 14-16, 2015
CANAC: Canadian Association of Nurses in AIDS Care
Ottawa, Canada
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June 9-12, 2015
7th SA AIDS Conference
Durban, South Africa
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July 19 to 22, 2015
IAS 2015
8th International AIDS Society Conference on HIV Pathogenesis, Treatment & Prevention
Vancouver, Canada
Abstracts Due: January 27!
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September 13-16, 2015
World STI & HIV 2015 Congress
Brisbane, Australia
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See full list of conferences
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| Production of this newsletter has been made possible through a financial contribution from the Public Health Agency of Canada. The views expressed herein do not necessarily represent the views of the Public Health Agency of Canada.
Third-Party E-bulletin Disclaimer
This E-Bulletin contains links to third party websites ("Linked Sites"), which are not under the control of ACO and ACO is not responsible for the contents of any Linked Site, including any link contained in a Linked Site or any changes or updates to a Linked Site. The Linked Sites may not be available in French or English. ACO is providing these links to you only as a convenience, and the inclusion of any link does not imply endorsement by ACO of the Linked Site or any association with its operators. We do not guarantee the accuracy of any information accessed through or published or provided by the Linked Site. You are responsible for viewing and abiding by the privacy statements and terms of use posted at the Linked Sites. Any specific comments or inquiries regarding the Linked Sites should be directed to the operator of the Linked Site.
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Copyright © 2015
Canadian HIV Vaccine Initiative Research and Development Alliance Coordinating Office
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